dendritic cells dc Search Results


93
Miltenyi Biotec dc marker
Dc Marker, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Miltenyi Biotec cd209 dc sign antibody
Cd209 Dc Sign Antibody, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 91 stars, based on 1 article reviews
cd209 dc sign antibody - by Bioz Stars, 2026-07
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Proteintech ccl18
Inhibition of 5‐HT 2B R by AM1476 modulates the expression of MAOB, SCL6A4, CCL2, CCL5, PAI‐1, and P‐STAT3 in murine cGvHD and PCS slices of SSc skin. (A and B) Murine cGvHD model. (A) Representative images of immunofluorescence staining and (B) quantification of Maob, Slc6a4, Ccl2, CCl5, Pai‐1, and P‐Stat3 in the skin of syngeneically and allogeneically transplanted mice with or without AM1476 treatment. All data are presented as mean ± SEM, with individual values displayed as column plus dots. Differences between the groups were tested for their statistical significance by one‐way analysis of variance with Dunnett's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the control allogenic group. (C and D) PCS slices of SSc skin. (C) Representative immunofluorescence staining images and (D) quantification of MAOB, SLC6A4, CCL2, <t>CCL18,</t> PAI‐1, and P‐STAT3 in SSc‐PCS with or without AM1476. All data points are presented as individual values displayed as dots. Differences between the groups were tested for their statistical significance by two‐way analysis of variance with Sidak's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the SSc‐PCS control group. 5‐HT 2B R, 5‐hydroxytryptamine 2B receptor; cGvHD, chronic graft‐versus‐host disease; PCS, precision cut skin; SSc, systemic sclerosis. Color figure can be viewed in the online issue, which is available at http://onlinelibrary.wiley.com/doi/10.1002/art.43151/abstract .
Ccl18, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/dendritic+cells+dc/pmc12311259-97-22-24?v=Proteintech
Average 93 stars, based on 1 article reviews
ccl18 - by Bioz Stars, 2026-07
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ProSci Incorporated anti dc sign
Inhibition of 5‐HT 2B R by AM1476 modulates the expression of MAOB, SCL6A4, CCL2, CCL5, PAI‐1, and P‐STAT3 in murine cGvHD and PCS slices of SSc skin. (A and B) Murine cGvHD model. (A) Representative images of immunofluorescence staining and (B) quantification of Maob, Slc6a4, Ccl2, CCl5, Pai‐1, and P‐Stat3 in the skin of syngeneically and allogeneically transplanted mice with or without AM1476 treatment. All data are presented as mean ± SEM, with individual values displayed as column plus dots. Differences between the groups were tested for their statistical significance by one‐way analysis of variance with Dunnett's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the control allogenic group. (C and D) PCS slices of SSc skin. (C) Representative immunofluorescence staining images and (D) quantification of MAOB, SLC6A4, CCL2, <t>CCL18,</t> PAI‐1, and P‐STAT3 in SSc‐PCS with or without AM1476. All data points are presented as individual values displayed as dots. Differences between the groups were tested for their statistical significance by two‐way analysis of variance with Sidak's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the SSc‐PCS control group. 5‐HT 2B R, 5‐hydroxytryptamine 2B receptor; cGvHD, chronic graft‐versus‐host disease; PCS, precision cut skin; SSc, systemic sclerosis. Color figure can be viewed in the online issue, which is available at http://onlinelibrary.wiley.com/doi/10.1002/art.43151/abstract .
Anti Dc Sign, supplied by ProSci Incorporated, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
anti dc sign - by Bioz Stars, 2026-07
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ISA Pharmaceuticals dendritic cell (dc) vaccines
Inhibition of 5‐HT 2B R by AM1476 modulates the expression of MAOB, SCL6A4, CCL2, CCL5, PAI‐1, and P‐STAT3 in murine cGvHD and PCS slices of SSc skin. (A and B) Murine cGvHD model. (A) Representative images of immunofluorescence staining and (B) quantification of Maob, Slc6a4, Ccl2, CCl5, Pai‐1, and P‐Stat3 in the skin of syngeneically and allogeneically transplanted mice with or without AM1476 treatment. All data are presented as mean ± SEM, with individual values displayed as column plus dots. Differences between the groups were tested for their statistical significance by one‐way analysis of variance with Dunnett's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the control allogenic group. (C and D) PCS slices of SSc skin. (C) Representative immunofluorescence staining images and (D) quantification of MAOB, SLC6A4, CCL2, <t>CCL18,</t> PAI‐1, and P‐STAT3 in SSc‐PCS with or without AM1476. All data points are presented as individual values displayed as dots. Differences between the groups were tested for their statistical significance by two‐way analysis of variance with Sidak's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the SSc‐PCS control group. 5‐HT 2B R, 5‐hydroxytryptamine 2B receptor; cGvHD, chronic graft‐versus‐host disease; PCS, precision cut skin; SSc, systemic sclerosis. Color figure can be viewed in the online issue, which is available at http://onlinelibrary.wiley.com/doi/10.1002/art.43151/abstract .
Dendritic Cell (Dc) Vaccines, supplied by ISA Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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dendritic cell (dc) vaccines - by Bioz Stars, 2026-07
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Becton Dickinson anti–dendritic cell-specific intercellular adhesion molecule-3–grabbing nonintegrin (dc-sign) abs
Inhibition of 5‐HT 2B R by AM1476 modulates the expression of MAOB, SCL6A4, CCL2, CCL5, PAI‐1, and P‐STAT3 in murine cGvHD and PCS slices of SSc skin. (A and B) Murine cGvHD model. (A) Representative images of immunofluorescence staining and (B) quantification of Maob, Slc6a4, Ccl2, CCl5, Pai‐1, and P‐Stat3 in the skin of syngeneically and allogeneically transplanted mice with or without AM1476 treatment. All data are presented as mean ± SEM, with individual values displayed as column plus dots. Differences between the groups were tested for their statistical significance by one‐way analysis of variance with Dunnett's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the control allogenic group. (C and D) PCS slices of SSc skin. (C) Representative immunofluorescence staining images and (D) quantification of MAOB, SLC6A4, CCL2, <t>CCL18,</t> PAI‐1, and P‐STAT3 in SSc‐PCS with or without AM1476. All data points are presented as individual values displayed as dots. Differences between the groups were tested for their statistical significance by two‐way analysis of variance with Sidak's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the SSc‐PCS control group. 5‐HT 2B R, 5‐hydroxytryptamine 2B receptor; cGvHD, chronic graft‐versus‐host disease; PCS, precision cut skin; SSc, systemic sclerosis. Color figure can be viewed in the online issue, which is available at http://onlinelibrary.wiley.com/doi/10.1002/art.43151/abstract .
Anti–Dendritic Cell Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin (Dc Sign) Abs, supplied by Becton Dickinson, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
anti–dendritic cell-specific intercellular adhesion molecule-3–grabbing nonintegrin (dc-sign) abs - by Bioz Stars, 2026-07
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BioCarta dendritic cell (dc) pathway gene set
Inhibition of 5‐HT 2B R by AM1476 modulates the expression of MAOB, SCL6A4, CCL2, CCL5, PAI‐1, and P‐STAT3 in murine cGvHD and PCS slices of SSc skin. (A and B) Murine cGvHD model. (A) Representative images of immunofluorescence staining and (B) quantification of Maob, Slc6a4, Ccl2, CCl5, Pai‐1, and P‐Stat3 in the skin of syngeneically and allogeneically transplanted mice with or without AM1476 treatment. All data are presented as mean ± SEM, with individual values displayed as column plus dots. Differences between the groups were tested for their statistical significance by one‐way analysis of variance with Dunnett's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the control allogenic group. (C and D) PCS slices of SSc skin. (C) Representative immunofluorescence staining images and (D) quantification of MAOB, SLC6A4, CCL2, <t>CCL18,</t> PAI‐1, and P‐STAT3 in SSc‐PCS with or without AM1476. All data points are presented as individual values displayed as dots. Differences between the groups were tested for their statistical significance by two‐way analysis of variance with Sidak's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the SSc‐PCS control group. 5‐HT 2B R, 5‐hydroxytryptamine 2B receptor; cGvHD, chronic graft‐versus‐host disease; PCS, precision cut skin; SSc, systemic sclerosis. Color figure can be viewed in the online issue, which is available at http://onlinelibrary.wiley.com/doi/10.1002/art.43151/abstract .
Dendritic Cell (Dc) Pathway Gene Set, supplied by BioCarta, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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dendritic cell (dc) pathway gene set - by Bioz Stars, 2026-07
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SuperArray Bioscience Corporation dendritic cell (dc)-specific microarrays
Inhibition of 5‐HT 2B R by AM1476 modulates the expression of MAOB, SCL6A4, CCL2, CCL5, PAI‐1, and P‐STAT3 in murine cGvHD and PCS slices of SSc skin. (A and B) Murine cGvHD model. (A) Representative images of immunofluorescence staining and (B) quantification of Maob, Slc6a4, Ccl2, CCl5, Pai‐1, and P‐Stat3 in the skin of syngeneically and allogeneically transplanted mice with or without AM1476 treatment. All data are presented as mean ± SEM, with individual values displayed as column plus dots. Differences between the groups were tested for their statistical significance by one‐way analysis of variance with Dunnett's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the control allogenic group. (C and D) PCS slices of SSc skin. (C) Representative immunofluorescence staining images and (D) quantification of MAOB, SLC6A4, CCL2, <t>CCL18,</t> PAI‐1, and P‐STAT3 in SSc‐PCS with or without AM1476. All data points are presented as individual values displayed as dots. Differences between the groups were tested for their statistical significance by two‐way analysis of variance with Sidak's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the SSc‐PCS control group. 5‐HT 2B R, 5‐hydroxytryptamine 2B receptor; cGvHD, chronic graft‐versus‐host disease; PCS, precision cut skin; SSc, systemic sclerosis. Color figure can be viewed in the online issue, which is available at http://onlinelibrary.wiley.com/doi/10.1002/art.43151/abstract .
Dendritic Cell (Dc) Specific Microarrays, supplied by SuperArray Bioscience Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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STEMCELL Technologies Inc dendritic cell (dc) vaccines
Inhibition of 5‐HT 2B R by AM1476 modulates the expression of MAOB, SCL6A4, CCL2, CCL5, PAI‐1, and P‐STAT3 in murine cGvHD and PCS slices of SSc skin. (A and B) Murine cGvHD model. (A) Representative images of immunofluorescence staining and (B) quantification of Maob, Slc6a4, Ccl2, CCl5, Pai‐1, and P‐Stat3 in the skin of syngeneically and allogeneically transplanted mice with or without AM1476 treatment. All data are presented as mean ± SEM, with individual values displayed as column plus dots. Differences between the groups were tested for their statistical significance by one‐way analysis of variance with Dunnett's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the control allogenic group. (C and D) PCS slices of SSc skin. (C) Representative immunofluorescence staining images and (D) quantification of MAOB, SLC6A4, CCL2, <t>CCL18,</t> PAI‐1, and P‐STAT3 in SSc‐PCS with or without AM1476. All data points are presented as individual values displayed as dots. Differences between the groups were tested for their statistical significance by two‐way analysis of variance with Sidak's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the SSc‐PCS control group. 5‐HT 2B R, 5‐hydroxytryptamine 2B receptor; cGvHD, chronic graft‐versus‐host disease; PCS, precision cut skin; SSc, systemic sclerosis. Color figure can be viewed in the online issue, which is available at http://onlinelibrary.wiley.com/doi/10.1002/art.43151/abstract .
Dendritic Cell (Dc) Vaccines, supplied by STEMCELL Technologies Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Northwest Biotherapeutics dc vax®l, autologous dendritic cells pulsed with tumor lysate antigen for the treatment of glioblastoma multiforme
Inhibition of 5‐HT 2B R by AM1476 modulates the expression of MAOB, SCL6A4, CCL2, CCL5, PAI‐1, and P‐STAT3 in murine cGvHD and PCS slices of SSc skin. (A and B) Murine cGvHD model. (A) Representative images of immunofluorescence staining and (B) quantification of Maob, Slc6a4, Ccl2, CCl5, Pai‐1, and P‐Stat3 in the skin of syngeneically and allogeneically transplanted mice with or without AM1476 treatment. All data are presented as mean ± SEM, with individual values displayed as column plus dots. Differences between the groups were tested for their statistical significance by one‐way analysis of variance with Dunnett's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the control allogenic group. (C and D) PCS slices of SSc skin. (C) Representative immunofluorescence staining images and (D) quantification of MAOB, SLC6A4, CCL2, <t>CCL18,</t> PAI‐1, and P‐STAT3 in SSc‐PCS with or without AM1476. All data points are presented as individual values displayed as dots. Differences between the groups were tested for their statistical significance by two‐way analysis of variance with Sidak's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the SSc‐PCS control group. 5‐HT 2B R, 5‐hydroxytryptamine 2B receptor; cGvHD, chronic graft‐versus‐host disease; PCS, precision cut skin; SSc, systemic sclerosis. Color figure can be viewed in the online issue, which is available at http://onlinelibrary.wiley.com/doi/10.1002/art.43151/abstract .
Dc Vax®L, Autologous Dendritic Cells Pulsed With Tumor Lysate Antigen For The Treatment Of Glioblastoma Multiforme, supplied by Northwest Biotherapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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dc vax®l, autologous dendritic cells pulsed with tumor lysate antigen for the treatment of glioblastoma multiforme - by Bioz Stars, 2026-07
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Northwest Biotherapeutics individualized dendritic cell-based vaccine for glioblastoma dc-vax-brain
Inhibition of 5‐HT 2B R by AM1476 modulates the expression of MAOB, SCL6A4, CCL2, CCL5, PAI‐1, and P‐STAT3 in murine cGvHD and PCS slices of SSc skin. (A and B) Murine cGvHD model. (A) Representative images of immunofluorescence staining and (B) quantification of Maob, Slc6a4, Ccl2, CCl5, Pai‐1, and P‐Stat3 in the skin of syngeneically and allogeneically transplanted mice with or without AM1476 treatment. All data are presented as mean ± SEM, with individual values displayed as column plus dots. Differences between the groups were tested for their statistical significance by one‐way analysis of variance with Dunnett's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the control allogenic group. (C and D) PCS slices of SSc skin. (C) Representative immunofluorescence staining images and (D) quantification of MAOB, SLC6A4, CCL2, <t>CCL18,</t> PAI‐1, and P‐STAT3 in SSc‐PCS with or without AM1476. All data points are presented as individual values displayed as dots. Differences between the groups were tested for their statistical significance by two‐way analysis of variance with Sidak's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the SSc‐PCS control group. 5‐HT 2B R, 5‐hydroxytryptamine 2B receptor; cGvHD, chronic graft‐versus‐host disease; PCS, precision cut skin; SSc, systemic sclerosis. Color figure can be viewed in the online issue, which is available at http://onlinelibrary.wiley.com/doi/10.1002/art.43151/abstract .
Individualized Dendritic Cell Based Vaccine For Glioblastoma Dc Vax Brain, supplied by Northwest Biotherapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Chemie GmbH human lectin dendritic cell-specific icam-3 grabbing nonintegrin (dc-sign)
Inhibition of 5‐HT 2B R by AM1476 modulates the expression of MAOB, SCL6A4, CCL2, CCL5, PAI‐1, and P‐STAT3 in murine cGvHD and PCS slices of SSc skin. (A and B) Murine cGvHD model. (A) Representative images of immunofluorescence staining and (B) quantification of Maob, Slc6a4, Ccl2, CCl5, Pai‐1, and P‐Stat3 in the skin of syngeneically and allogeneically transplanted mice with or without AM1476 treatment. All data are presented as mean ± SEM, with individual values displayed as column plus dots. Differences between the groups were tested for their statistical significance by one‐way analysis of variance with Dunnett's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the control allogenic group. (C and D) PCS slices of SSc skin. (C) Representative immunofluorescence staining images and (D) quantification of MAOB, SLC6A4, CCL2, <t>CCL18,</t> PAI‐1, and P‐STAT3 in SSc‐PCS with or without AM1476. All data points are presented as individual values displayed as dots. Differences between the groups were tested for their statistical significance by two‐way analysis of variance with Sidak's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the SSc‐PCS control group. 5‐HT 2B R, 5‐hydroxytryptamine 2B receptor; cGvHD, chronic graft‐versus‐host disease; PCS, precision cut skin; SSc, systemic sclerosis. Color figure can be viewed in the online issue, which is available at http://onlinelibrary.wiley.com/doi/10.1002/art.43151/abstract .
Human Lectin Dendritic Cell Specific Icam 3 Grabbing Nonintegrin (Dc Sign), supplied by Chemie GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Inhibition of 5‐HT 2B R by AM1476 modulates the expression of MAOB, SCL6A4, CCL2, CCL5, PAI‐1, and P‐STAT3 in murine cGvHD and PCS slices of SSc skin. (A and B) Murine cGvHD model. (A) Representative images of immunofluorescence staining and (B) quantification of Maob, Slc6a4, Ccl2, CCl5, Pai‐1, and P‐Stat3 in the skin of syngeneically and allogeneically transplanted mice with or without AM1476 treatment. All data are presented as mean ± SEM, with individual values displayed as column plus dots. Differences between the groups were tested for their statistical significance by one‐way analysis of variance with Dunnett's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the control allogenic group. (C and D) PCS slices of SSc skin. (C) Representative immunofluorescence staining images and (D) quantification of MAOB, SLC6A4, CCL2, CCL18, PAI‐1, and P‐STAT3 in SSc‐PCS with or without AM1476. All data points are presented as individual values displayed as dots. Differences between the groups were tested for their statistical significance by two‐way analysis of variance with Sidak's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the SSc‐PCS control group. 5‐HT 2B R, 5‐hydroxytryptamine 2B receptor; cGvHD, chronic graft‐versus‐host disease; PCS, precision cut skin; SSc, systemic sclerosis. Color figure can be viewed in the online issue, which is available at http://onlinelibrary.wiley.com/doi/10.1002/art.43151/abstract .

Journal: Arthritis & Rheumatology (Hoboken, N.j.)

Article Title: Antifibrotic effects of specific targeting of the 5‐hydroxytryptamine 2B receptor (5‐HT 2B R) in murine models and ex vivo models of scleroderma skin

doi: 10.1002/art.43151

Figure Lengend Snippet: Inhibition of 5‐HT 2B R by AM1476 modulates the expression of MAOB, SCL6A4, CCL2, CCL5, PAI‐1, and P‐STAT3 in murine cGvHD and PCS slices of SSc skin. (A and B) Murine cGvHD model. (A) Representative images of immunofluorescence staining and (B) quantification of Maob, Slc6a4, Ccl2, CCl5, Pai‐1, and P‐Stat3 in the skin of syngeneically and allogeneically transplanted mice with or without AM1476 treatment. All data are presented as mean ± SEM, with individual values displayed as column plus dots. Differences between the groups were tested for their statistical significance by one‐way analysis of variance with Dunnett's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the control allogenic group. (C and D) PCS slices of SSc skin. (C) Representative immunofluorescence staining images and (D) quantification of MAOB, SLC6A4, CCL2, CCL18, PAI‐1, and P‐STAT3 in SSc‐PCS with or without AM1476. All data points are presented as individual values displayed as dots. Differences between the groups were tested for their statistical significance by two‐way analysis of variance with Sidak's multiple comparison. Adjusted P values less than 0.05 were considered significant. Adjusted P values are expressed as follows: *0.05 > P > 0.01; **0.01 > P > 0.001; ***0.001 > P > 0.0001; **** P < 0.0001 as compared to the SSc‐PCS control group. 5‐HT 2B R, 5‐hydroxytryptamine 2B receptor; cGvHD, chronic graft‐versus‐host disease; PCS, precision cut skin; SSc, systemic sclerosis. Color figure can be viewed in the online issue, which is available at http://onlinelibrary.wiley.com/doi/10.1002/art.43151/abstract .

Article Snippet: The staining of skin sections was performed by using the antibodies against CCL2 (LS‐C169178‐100, LSBio, 1:100 dilution), CCL5 (MAB478‐100, Biotechne, 1:100 dilution), CCL18 (22303‐1‐AP, Proteintech, 1:100 dilution), PAI‐1 (66261‐1‐Ig, Proteintech, 1:100 dilution), P‐STAT3 (MA5‐15193, Thermo Scientific, 1:100 dilution), MAOB (12602‐1‐AP, Proteintech, 1:100 dilution), or SLC6A4 (LS‐C154958‐100, LSBio, 1:100 dilution).

Techniques: Inhibition, Expressing, Immunofluorescence, Staining, Comparison, Control